Cannabis varieties rich in CBD differ in the pharmacological effects of THC-rich

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CBD is one of over 60+ compounds found in cannabis that belong to a class of molecules called cannabinoids. Of these compounds, CBD and THC are usually present in the highest concentrations, and are therefore the most recognized and studied. We at CBD Crew are using cannabis to create our strains, not hemp. All our genetics will have traces of all canabinoids found naturally in the plants genetics, as we believe in the entourage effect of  the plant to be the most effective for most patients.

CBD and THC levels tend to vary between different strains and varieties of cannabis.  By using selective breeding techniques, we have managed to create varieties with high levels of CBD and THC.

CBD does not cause a high, unlike THC. The reason why CBD is non-psychoactive is due to its lack of affinity for CB1 receptors. CB1 receptors are found in high concentrations in the brain, and are the pathways responsible for the psychoactive effects of THC.

Numerous studies suggest CBD acts to counter the intoxicating effects of THC, including memory impairment and paranoia. But cannabis with both CBD & THC is still psychoactive, just at a different level.

Both CBD and THC have been found to present no risk of lethal overdose. However, to reduce potential side effects, medical users may be better off using cannabis strains with higher levels of CBD.

CBD/THC & Alzheimer

 Dr. Tim Karl and his colleagues found that, when given CBD, mice bred to mimic Alzheimer’s showed drastic improvements in tests involving the recognition of objects and other mice. Patients who suffer from Alzheimer’s disease tend to forget familiar faces, along with symptoms of more widespread memory loss, the team notes.

“You could say it cured them”The results were presented at the Australian Neuroscience Society’s 2013 annual meeting and were published this week in Psychopharmacology.

CBD/THC & Epilepsy

 We have seen a huge amount of children with epilepsy that has benefited enormous from getting high CBD rich cannabis as treatment. Many children like Charlotte Figi, who was having 300 grand mal seizures a week and Jayden and his dad Jason, who also decided to try cannabis with high CBD as a treatment option. There are loads of people reporting about huge benefits from using CBD/THC for treating epileptic seizures. And many share their stories on channels like Youtube and Facebook for everybody to learn from their experiences and now many studies have been done and are being done on this as wel

CBD/THC & Cancer

CBD (cannabidiol)  can also stop metastasis in many types of aggressive cancers. Metastasis is the spread of disease from one organ or part to another non-adjacent organ or part.

Sean McAllister, one of the researchers at California Pacific, was studying the effects of Cannabidiol(CBD). Pierre Desprez, a molecular biologist researcher, began studying ID-1, the gene that causes cancer to spread, about 20 years ago. The two combined their research and introduced CBD to cancer cells containing ID-1 in a petri dish. They found that CBD stopped the metastasis of the cancer cells.

Research conducted with 102 patients in the Netherlands, who consumed three different varieties of cannabis for medicinal purposes pharmacies show that the pharmacological effects differ depending on the proportion of THC and CBD.

These studies have been carried out by the Netherlands Institute of Mental Health and Addiction in Utrecht and the Office of Medicinal Cannabis of the Dutch Health Ministry and published in the Journal of Psychopharmacology. 47% of patients consumed the variety Bedrocan with 19% THC and less than 1% of CBD, the Bedrobinol range 28.5% to 12% THC and less than 1% of CBD, and 24 ‘ 5% Bediol with nearly equal amounts of THC (6%) and CBD (7.5%). Statistical analysis revealed the subjective effects of the high THC in varieties Bedrobinol Bedrocan and resulted in an increase in appetite compared with Bediol. There was also a higher level of anxiety and depression in the group that consumed compared Bedrocan took Bediol.

The most common cannabis medical indication was a chronic pain (53%), followed by multiple sclerosis (23%), and 86% of patients experienced therapeutic satisfaction regardless of the variety of cannabis used. The study authors say that “these results show that patients relate satisfactorily with therapeutic pharmaceutical cannabis, mainly pain relief.” The amount of cannabis used did not differ between the different strains. With regard to the different effects, the authors suggest that “the CBD can have a modulating effect on some of the known subjective side effects of THC, such as anxiety and depressed mood”.

Cannabidiol improved sleep-related disorder in Parkinson’s

The natural cannabinoid cannabidiol (CBD) is able to control the symptoms of the disorder of REM sleep behavior. This is the result of four cases investigated by the Department of Neuroscience and Behavior of the Faculty of Medicine of Ribeirao Preto, University of São Paulo, Brazil.

The disorder of REM sleep behavior is characterized by loss of muscle weakness during REM sleep associated with nightmares and sleeping active behavior. The researchers describe the effects of CBD in these symptoms in patients with Parkinson’s disease. They saw that the four patients treated with CBD had a rapid and substantial reduction of the frequency of events related to the disorder of REM sleep behavior without presenting side effects. The phase of rapid eye movement (REM) stage of sleep is characterized by a rapid and random movement of the eyes. Souvenirs vivid dreams occur mostly during REM sleep.

 The Epidiolex CBD extract is effective in children with refractory epilepsy

 An experimental CBD extract of the British company GW Pharmaceuticals has produced promising results in a small study of children with epilepsy of difficult treatment. The latest findings of its new product Epidiolex are the result of the monitoring and evaluation of 27 children and young adults with refractory epilepsy to those who are given the drug in two hospitals in the United States. The Epidiolex is administered as a syrup flavored strawberry-lime twice daily. The drug does not contain THC.

 GW said on June 17 that after 12 weeks of treatment in an open label study results are “encouraging”, with a reduction in seizure frequency of more than 50 percent. Now plans to initiate a clinical trial phase II / III in the second half of the year. The CBD can help children with severe epilepsy syndromes such as Lennox-Gastaut and Dravet, where attacks often persist despite high doses of several anti-epileptic drugs.

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