Breast Cancer Treatment With Aromasin

Healthinfi

Aromasin is a cancer treatment medicine, which comes with multiple benefits as well as some side effects too. Like any other cancer medicine there will be side effects but the benefits are good enough to weigh down the side effects. The main application of this product is in breast cancer treatment. Several types of breast cancer can be treated with the medicine. Aromasin generic is also referred to as Aromasin Exemestane. It also inhibits cancer from returning.

In women the hormone estrogen plays a bad role in naturally increasing the size and spread of cancer cells. This can be reversed and stopped when the amount of estrogen released on body can be controlled and stopped. The medicine does the same. But that is one reason, that it is not used on women who are still fertile and in child bearing age. Aromasin (chemical name: exemestane) is an aromatase inhibitor approved by the U.S. Food and Drug Administration (FDA) to treat:

  • postmenopausal women diagnosed with hormone-receptor-positive, early-stage breast cancer after they’ve taken tamoxifen for 2 to 3 years to reduce the risk of the cancer coming back
  • postmenopausal women diagnosed with advanced-stage or metastatic hormone-receptor-positive breast cancer

Women stop taking tamoxifen when they start taking Aromasin.

Aromatase inhibitors can’t stop the ovaries from making estrogen, so aromatase inhibitors are mainly used to treat postmenopausal women. But because aromatase inhibitors are so much more effective than tamoxifen in postmenopausal women, researchers wondered if there were a way to successfully treat premenopausal women diagnosed with hormone-receptor-positive, early-stage breast cancer with an aromatase inhibitor. Results from the SOFT (Suppression of Ovarian Function Trial) study published in 2015 suggest that premenopausal women diagnosed with hormone-receptor-positive breast cancer can be successfully treated with Aromasin if their ovarian function is suppressed. If you’re a premenopausal woman willing to take medicine to suppress your ovaries, you may be able to take Aromasin instead of tamoxifen for your hormonal therapy treatment.

Aromasin won’t work on hormone-receptor-negative breast cancer.

Aromasin is a pill taken once a day. Most doctors recommend taking Aromasin at the same time each day. You should not take Aromasin if you are breastfeeding, pregnant, trying to get pregnant, or if there is any chance that you could be pregnant. Aromasin may cause damage to developing embryos. You should use an effective non-hormonal type of birth control — such as condoms, a diaphragm along with spermicide, or a non-hormonal I.U.D. – while you are taking Aromasin. Ask your doctor which type of non-hormonal birth control would be best for you, as well as how long you should use this type of birth control after you stop taking Aromasin.

Aromasin Works

Exemestane is a type of hormone therapy drug included in the group of aromatase inhibitor drugs, and defined by the National Cancer Institute (NCI) Drug Dictionary as a “synthetic androgen analogue” that “binds irreversibly to and inhibits the enzyme aromatase, thereby blocking the conversion of cholesterol to pregnenolone and the peripheral aromatization of androgenic precursors into estrogens.” The drug is used for the treatment of breast cancer and it is usually taken in the form of tablets once a day after a meal over the course of a few years. The mechanism of action of exemestane is based on addressing the hormones that stimulate breast cancer growth.

In menstruating women the growth of breast cancer is promoted by female sex hormones called estrogen and progesterone, which are produced in the ovaries. In menopausal women the production of these hormones no longer occur in the ovaries. After menopause, hormones are mainly produced through a process that transform androgens sex hormones produced by the adrenal glands — into estrogen. This transformation is called aromatase. Exemestane works by blocking aromatase in order to decrease the levels of estrogen in the body and stop cancer growth or breast cancer recurrence.

Aromasin for Breast Cancer

Exemestane was approved by the U.S. FDA in October 2005. The drug is commercialized under the brand name Aromasin by Pfizer, and is used as an adjuvant treatment in postmenopausal women who suffer from estrogen receptor positive early-stage breast cancer. Women generally begin taking exemestane after they’ve been on tamoxifen for two to three years, then switch to exemestane for two to three years, for a total of five consecutive years of adjuvant hormonal therapy.

The FDA’s approval of the drug was based on a double-blind, multi-center, international clinical trial that included 4,724 postmenopausal women with early stage breast cancer, known as the Intergroup Exemestane Study (IES).

“After a median duration of randomized therapy of 27 months and with a median duration of follow-up of 34.5 months, DFS [disease-free survival] was significantly improved in patients who switched to exemestane compared to those who continued tamoxifen,” according to the NCI. “In the hormone receptor-positive subpopulation representing about 85 percent of the trial patients, DFS was significantly improved in the exemestane arm compared to the tamoxifen arm.”

The same study indicated that the most common side effects from the treatment include hot flashes, fatigue, joint pain, headache, insomnia, increased sweating, hypertension, and dizziness. More rare adverse events, such as heart problems, can also occur.

Breast Cancer News is strictly a news and information website about the disease. It does not provide medical advice, diagnosis or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.

Aromasin with afinitor

Aromasin Afinitor is a combination where the combo of the two drugs Aromasin and Affinitor helps reduce the symptoms of advanced breast cancer in patients. As a result the growth and advancement of the cancer in advanced stages is slowed. This results in a longer life of the patients.

Benefits of Aromasin

The large IES (Intergroup Exemestane Study) trial was started in 1998 and compared switching to Aromasin after taking tamoxifen for 2 to 3 years to staying on tamoxifen for 5 years. The results have shown that switching to Aromasin for 2 to 3 years AFTER taking tamoxifen 2 to 3 years (for a total of 5 years of hormonal therapy medicine) was better than staying on tamoxifen for 5 years for:

  • increasing the time before the cancer comes back in those who experience a recurrence
  • reducing the risk of a new cancer developing in the other breast

for postmenopausal women diagnosed with hormone-receptor-positive, early-stage breast cancer.

Research published in 2011 showed that Aromasin can lower risk in high-risk, postmenopausal women who’ve never been diagnosed with breast cancer. Aromasin is not approved by the FDA for this use, but doctors may consider it a good alternative to tamoxifen or Evista. In 2013, the American Society of Clinical Oncology (ASCO) released new guidelines on using hormonal therapy medicines to reduce breast cancer risk in high-risk women. These guidelines recommend that doctors talk to high-risk postmenopausal women about using Aromasin to reduce risk. ASCO is a national organization of oncologists and other cancer care providers. ASCO guidelines give doctors recommendations for treatments that are supported by much credible research and experience.

It’s possible that the FDA may approve Aromasin to be used to reduce risk in high-risk, postmenopausal women who haven’t been diagnosed.

Side effects Aromasin

The common side effects of Aromasin are hair loss, hot flashes, joint pains, bone pains, dizziness, excessive sweating, diarrhea, nausea, insomnia and tiredness.

If the side effects worsens and you experience more troubles like unexplained vaginal bleeding, severe depression or mood swings, bone fractures, extreme tiredness or nausea and vomiting , yellow eyes and skin, and dark colored urine, then you must instantly tell the doctor about it.
Problems and case histories including blood clot formations, bone problems, heart problems, cholesterol issues, and kidney and liver related problems must be discussed with the doctor.
Precautions while taking the medicine

The drug is taken once a day orally. It has to be taken as told by the doctor. Pregnant women are at risk from the drug, and hence no pregnant women should handle this or get exposed to this. The drug may enter body through skin and lungs too, and hence inhaling the dust of the tablets may pose problem for pregnant women.
Based on the severity patients may get an increased or decreased dose of the drug. If you see that breast lumps are worsened you must immediately report the doctor.
Estrogens and estrogen blocking drugs can interfere with the activity of the medicine. Hence you must discuss all the drugs you are taking when you are prescribed this medicine.
How it is used in body building?

In many males the amount of estrogen is high in the body giving in unwanted side effects like enlarged breast tissues and reduction or conversion of testosterone into other forms that are not good for a muscular and masculine body. Hence the best way to stop this is by inhibiting the main causative enzyme behind this which is aromatase. Aromatase can be stopped from producing estrogen when Aromasin is taken. As a result a muscular body can be easily achieved through body building efforts. That is why body builders use Aromasin bodybuilding therapy.
The tablets are available online and one may get the cost or price list online from relevant websites.

Because Aromasin lowers the amount of estrogen in the body, less estrogen reaches bone cells, which can lead to bone thinning and weakening and a higher-than-average risk of broken bones. This side effect can be very troubling for some women. If you have osteoporosis, your doctor may recommend that you take tamoxifen rather than Aromasin because of this possible side effect.

Other common side effects of Aromasin are:

  • bone and joint pain
  • hot flashes
  • fatigue
  • headache
  • insomnia
  • increased sweating

Some women may have other side effects while taking Aromasin:

  • nervousness
  • dizziness
  • dry skin
  • diarrhea
  • vision changes
  • hair changes

Some side effects may mean that you’re having an allergic reaction to Aromasin. If you have shortness of breath or chest pain, call your doctor immediately.

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